Anti-EBV Nuclear Antigen/EBNA1 抗体 [E1-2.5] (ab8329)
Key features and details
- Mouse monoclonal [E1-2.5] to EBV Nuclear Antigen/EBNA1
- Suitable for: IHC-P, ICC, ELISA
- Isotype: IgG2b
製品の概要
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製品名
Anti-EBV Nuclear Antigen/EBNA1 antibody [E1-2.5]
EBV Nuclear Antigen/EBNA1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [E1-2.5] to EBV Nuclear Antigen/EBNA1 -
由来種
Mouse -
特異性
Recognizes repetitive gly-ala region of the nuclear antigen 1 of Epstein Barr virus (EBNA-1). -
アプリケーション
適用あり: IHC-P, ICC, ELISAmore details -
種交差性
交差種: Epstein-Barr virus -
免疫原
Synthetic peptide. Corresponding to the repetitive Gly-Ala region of EBNA1.
Database link: P03211 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.097% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
E1-2.5 -
アイソタイプ
IgG2b -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab8329の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
Use at an assay dependent concentration. PubMed: 18258188
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ICC |
Use at an assay dependent concentration.
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ELISA |
Use at an assay dependent concentration.
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特記事項 |
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IHC-P
Use at an assay dependent concentration. PubMed: 18258188 |
ICC
Use at an assay dependent concentration. |
ELISA
Use at an assay dependent concentration. |
ターゲット情報
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関連性
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is the one EBV antigen that is expressed in all EBV associated malignancies. It has long been thought to go undetected by the cell mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV related cancers. -
細胞内局在
Nuclear. Free in the nucleoplasm, somewhat associated with the chromatin and hardly, if at all associated with the nuclear matrix. -
参照データベース
- SwissProt: P03211 Epstein-Barr virus
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別名
- EBNA1 antibody
- EBV nuclear antigen 1 antibody
- Epstein Barr nuclear antigen 1 antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (8)
ab8329 は 8 報の論文で使用されています。
- Julius P et al. Epstein-Barr Virus, But Not Human Papillomavirus, Is Associated With Preinvasive and Invasive Ocular Surface Squamous Neoplasias in Zambian Patients. Front Oncol 12:864066 (2022). PubMed: 35494029
- Wang H et al. The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein-Barr virus by inhibiting the molecular chaperone function of Hsp70. Cell Death Dis 9:734 (2018). PubMed: 29959331
- Wang C et al. Berberine inhibits the proliferation of human nasopharyngeal carcinoma cells via an Epstein-Barr virus nuclear antigen 1-dependent mechanism. Oncol Rep 37:2109-2120 (2017). PubMed: 28259949
- Ni C et al. In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures. Cell Res 25:785-800 (2015). PubMed: 25916549
- Cardinaud S et al. The synthesis of truncated polypeptides for immune surveillance and viral evasion. PLoS One 5:e8692 (2010). PubMed: 20098683
- Fawzy S et al. Detection of Epstein-Barr virus in breast carcinoma in Egyptian women. Clin Biochem 41:486-92 (2008). IHC-P . PubMed: 18258188
- Haque T et al. Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial. Blood 110:1123-31 (2007). IHC-P . PubMed: 17468341
- McClain MT et al. An altered immune response to Epstein-Barr nuclear antigen 1 in pediatric systemic lupus erythematosus. Arthritis Rheum 54:360-8 (2006). PubMed: 16385527