Anti-E2F8 抗体 (ab185727)
Key features and details
- Rabbit polyclonal to E2F8
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-E2F8 antibody
E2F8 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to E2F8 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Cow -
免疫原
Recombinant full length protein corresponding to Human E2F8 aa 1 to the C-terminus.
Database link: A0AVK6 -
ポジティブ・コントロール
- HeLa cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab185727の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/2000. Predicted molecular weight: 94 kDa.
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特記事項 |
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WB
1/500 - 1/2000. Predicted molecular weight: 94 kDa. |
ターゲット情報
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機能
Along with E2F7, inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Directly represses E2F1 transcription. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession. -
配列類似性
Belongs to the E2F/DP family. -
ドメイン
Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 786629 Cow
- Entrez Gene: 79733 Human
- Entrez Gene: 108961 Mouse
- Entrez Gene: 308607 Rat
- Omim: 612047 Human
- SwissProt: E1BKK0 Cow
- SwissProt: A0AVK6 Human
- SwissProt: Q58FA4 Mouse
see all -
別名
- E2F 8 antibody
- E2F family member 82 antibody
- E2F transcription factor 8 antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab185727 は 1 報の論文で使用されています。
- Sun J et al. E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycle. J Exp Clin Cancer Res 36:40 (2017). PubMed: 28270228