Dexamethasone sodium phosphate, glucocorticoid receptor agonist (ab142419)
Key features and details
- Potent glucocorticoid receptor agonist. Dexamethasone prodrug.
- CAS Number: 2392-39-4
- Purity: > 98%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
-
製品名
Dexamethasone sodium phosphate, glucocorticoid receptor agonist -
製品の詳細
Potent glucocorticoid receptor agonist. Dexamethasone prodrug. -
生理活性の詳細
Potent glucocorticoid receptor agonist and dexamethasone prodrug (ab120743). Multiple effects on cell survival, cell signaling and gene expression. Anti-inflammatory and immunosupressant. Active in vivo.
-
精製度
> 98% -
CAS 番号
2392-39-4 -
構造式
製品の特性
-
体系名
(11β,16α)-9-Fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione disodium salt -
分子量
516.41 -
分子式
C22H28FNa2O8P -
PubChem 登録番号
16961 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES 線形表記
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+] -
由来
Synthetic
-
研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab142419 は 1 報の論文で使用されています。
- Bangs FK et al. Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse. Dis Model Mech 13:N/A (2020). PubMed: 32571902