Anti-Desmin 抗体 (ab80503)
Key features and details
- Goat polyclonal to Desmin
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Desmin antibody
Desmin 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to Desmin -
由来種
Goat -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse
交差が予測される動物種: Cow, Dog -
免疫原
Synthetic peptide:
C-RDGEVVSEATQQQHE
, corresponding to C terminal amino acids 454 - 468 of Human Desmin (NP_001918.3) -
ポジティブ・コントロール
- WB: Mouse skeletal muscle.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, Tris buffered saline -
Concentration information loading...
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精製度
Ammonium Sulphate Precipitation -
特記事項(精製)
ab80503 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab80503の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 54 kDa.
1 hour primary incubation is recommended for this product. |
特記事項 |
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WB
Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 54 kDa. 1 hour primary incubation is recommended for this product. |
ターゲット情報
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機能
Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. -
関連疾患
Defects in DES are the cause of myopathy myofibrillar desmin-related (MFM-DES) [MIM:601419]; also known as desmin-related myopathy (DRM). A neuromuscular disorder characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by myofibrillar destruction with intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells.
Defects in DES are the cause of cardiomyopathy dilated type 1I (CMD1I) [MIM:604765]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in DES are the cause of neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome) [MIM:181400]. Kaeser syndrome is an autosomal dominant disorder with a peculiar scapuloperoneal distribution of weakness and atrophy. A large clinical variability is observed ranging from scapuloperoneal, limb grindle and distal phenotypes with variable cardiac or respiratory involvement. Facial weakness, dysphagia and gynaecomastia are frequent additional symptoms. Affected men seemingly bear a higher risk of sudden, cardiac death as compared to affected women. Histological and immunohistochemical examination of muscle biopsy specimens reveal a wide spectrum of findings ranging from near normal or unspecific pathology to typical, myofibrillar changes with accumulation of desmin. -
配列類似性
Belongs to the intermediate filament family. -
細胞内局在
Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 280765 Cow
- Entrez Gene: 497091 Dog
- Entrez Gene: 13346 Mouse
- SwissProt: O62654 Cow
- SwissProt: Q5XFN2 Dog
- SwissProt: P31001 Mouse
- Unigene: 6712 Mouse
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別名
- CMD1I antibody
- CSM1 antibody
- CSM2 antibody
see all
画像
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (5)
ab80503 は 5 報の論文で使用されています。
- Han B et al. Fat-associated lymphoid clusters as expandable niches for ectopic liver development. Hepatology 76:357-371 (2022). PubMed: 34890068
- Song K et al. Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance. Stroke Vasc Neurol 7:222-236 (2022). PubMed: 35101948
- Lamotte JD et al. hiPSC-Derived Neurons Provide a Robust and Physiologically Relevant In Vitro Platform to Test Botulinum Neurotoxins. Front Pharmacol 11:617867 (2020). PubMed: 33519485
- Shimizu Y et al. Angiotensin II subtype 1a receptor signaling in resident hepatic macrophages induces liver metastasis formation. Cancer Sci 108:1757-1768 (2017). IHC-P ; Mouse . PubMed: 28660748
- Zhao X et al. Spontaneous immortalization of mouse liver sinusoidal endothelial cells. Int J Mol Med 35:617-24 (2015). ICC/IF ; Mouse . PubMed: 25585915