Anti-DHCR7 抗体 (ab103296)
Key features and details
- Rabbit polyclonal to DHCR7
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-DHCR7 antibody
DHCR7 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to DHCR7 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Rat, Human -
免疫原
Fragment protein corresponding to amino acids 1-259 of Human DHCR7 (NP_001351.2).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.4
Constituent: PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab103296の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 54 kDa.
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特記事項 |
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WB
1/500 - 1/1000. Predicted molecular weight: 54 kDa. |
ターゲット情報
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関連性
The DHCR7 gene encodes delta-7-sterol reductase (EC 1.3.1.21), the penultimate enzyme of mammalian sterol biosynthesis that converts 7-dehydrocholesterol (7-DHC) to cholesterol. This enzyme removes the C(7-8) double bond introduced by the sterol delta8-delta7 isomerases. In addition, its role in drug-induced malformations is known: inhibitors of the last step of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development (Moebius et al., 1998 [PubMed 9465114]).[OMIM] -
細胞内局在
Endoplasmic reticulum membrane; Multi-pass membrane protein -
参照データベース
- Entrez Gene: 1717 Human
- Entrez Gene: 13360 Mouse
- Entrez Gene: 64191 Rat
- Omim: 602858 Human
- SwissProt: Q9UBM7 Human
- SwissProt: O88455 Mouse
- SwissProt: Q9Z2Z8 Rat
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別名
- 7 dehydrocholesterol reductase antibody
- 7 DHC reductase antibody
- Delta 7 dehydrocholesterol reductase antibody
see all
画像
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Anti-DHCR7 antibody (ab103296) at 1/500 dilution + Rat brain tissue lysate at 50 µg
Predicted band size: 54 kDa -
Anti-DHCR7 antibody (ab103296) at 1/500 dilution + Mouse testis tissue lysate at 50 µg
Predicted band size: 54 kDa -
Anti-DHCR7 antibody (ab103296) at 1/500 dilution + HepG2 cell lysate at 50 µg
Predicted band size: 54 kDa
データシートおよび資料
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Datasheet download
参考文献 (7)
ab103296 は 7 報の論文で使用されています。
- Azar C et al. RNA-Seq identifies genes whose proteins are upregulated during syncytia development in murine C2C12 myoblasts and human BeWo trophoblasts. Physiol Rep 9:e14671 (2021). PubMed: 33403800
- Findakly S et al. Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway. J Cell Biol 220:N/A (2021). PubMed: 33284321
- Zhang P et al. Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Nat Med 23:1055-1062 (2017). PubMed: 28805822
- Pirhaji L et al. Revealing disease-associated pathways by network integration of untargeted metabolomics. Nat Methods 13:770-6 (2016). PubMed: 27479327
- Fryer LG et al. The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis. J Biol Chem 289:4244-61 (2014). WB ; Human . PubMed: 24338480
- Sugiyama K et al. Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus. PLoS One 9:e94460 (2014). WB, IF ; Human . PubMed: 24718268
- Sims-Robinson C et al. The role of oxidative stress in nervous system aging. PLoS One 8:e68011 (2013). WB . PubMed: 23844146