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Anti-Cyclin E antibody (ab2094)

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Overview

Product name

Anti-Cyclin E antibody
Cyclin E 抗体 (22件) 一覧

Description

Rabbit polyclonal to Cyclin E

Specificity

Antiserum will specifically react with a 45 kDa Cyclin E protein from human, rat and mouse tissue. No reaction was observed against other related cyclins.

Tested applications

WB, IP, ELISAmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Full length synthetic polypeptide corresponding to the human gene sequence

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.01% Sodium Azide

Purity

Whole antiserum

Purification notes

Delipidated, defibrinated and sterile filtered monospecific antiserum.

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Cell cycle >> Cyclins >> Cyclin E family
Epigenetics and Nuclear Signaling >> Cell cycle >> Cyclins >> Cyclin E Family
Cell Biology >> Cell Cycle >> Cyclins >> Cyclin E Family
Cell Biology >> Cell Cycle >> Cyclins

Applications

Show applications key

Our Abpromise guarantee covers the use of ab2094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    WB

     WB: 1/200 - 1/500.Predic...Read more →

    WB: 1/200 - 1/500.Predicted molecular weight: 47 kDa.

  • ShowHide

    IP

     IP: Use at an assay depe...Read more →

    IP: Use at an assay dependent dilution.

  • ELISA

     ELISA: 1/2000

    ELISA: 1/2000

Target

Relevance

Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

Cellular localization

Nuclear

Alternative names

  • CCNE 1 antibody
  • CCNE antibody
  • CCNE1 antibody
  • Cyclin E1 antibody
  • Cyclin Es antibody
  • Cyclin Et antibody
  • CyclinE antibody
  • G1/S specific cyclin E antibody
see all

Database links

References for Anti-Cyclin E antibody (ab2094)

This product has been referenced in:

  • Ferguson RL & Maller JL Cyclin E-dependent localization of MCM5 regulates centrosome duplication. J Cell Sci 121:3224-32 (2008). ICC/IF; Human.Read more (PubMed: 18799789) »
  • Rao HVet al. Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neurons. J Neurochem 101:498-505 (2007). WB; Rat.Read more (PubMed: 17254021) »

See all 2 publications for this product

Publishing research using ab2094? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"