Chelerythrine chloride, Cell-permeable protein kinase C inhibitor (ab120600)
Key features and details
- Cell-permeable, selective protein kinase C inhibitor. Apoptosis inducer.
- CAS Number: 3895-92-9
- Purity: > 98%
- Soluble in DMSO to 10 mM and in water to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Chelerythrine chloride, Cell-permeable protein kinase C inhibitor -
製品の詳細
Cell-permeable, selective protein kinase C inhibitor. Apoptosis inducer. -
別名
- 1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride
- Toddalin chloride
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精製度
> 98% -
CAS 番号
3895-92-9 -
構造式
製品の特性
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体系名
1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride -
分子量
383.83 -
分子式
C21H18ClNO4 -
PubChem 登録番号
72311 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 10 mM and in water to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (3)
ab120600 は 3 報の論文で使用されています。
- Wan KF et al. Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism. J Biol Chem 283:8423-33 (2008). PubMed: 18230621
- Yu R et al. Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. J Biol Chem 275:9612-9 (2000). PubMed: 10734112
- Herbert JM et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 172:993-9 (1990). PubMed: 2244923