![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cdc7 Kinase antibody [SPM171] (ab17880) image](#ab17880_1.jpg)
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Products:Cell Biology >> Cell Cycle >> Kinases/Phosphatases >> Other
Overview
Product name
Anti-Cdc7 Kinase antibody [SPM171]
Cdc7 Kinase 抗体 (10件) 一覧
Description
Mouse monoclonal [SPM171] to Cdc7 Kinase
Tested applications
WB, IP, IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant full length protein (Human).
Positive control
Hela cells. Tonsil.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: BSA, 10mM PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
SPM171
Isotype
IgG1
Light chain type
kappa
Research areas
Epigenetics and Nuclear Signaling >> Cell cycle >> Kinases/Phosphatases >> Cdks
Cell Biology >> Cell Cycle >> Kinases/Phosphatases >> Other
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cdc7 Kinase antibody [SPM171] (ab17880)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cdc7 Kinase antibody [SPM171] (ab17880) image](/ps/datasheet/Images/17/ab17880/ab17880_1.jpg)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab17880 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Detects a band of approximately 55 kDa (predicted molecular weight: 64 kDa).
IP: Use at an assay dependent dilution.
IHC-P: 1/50Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Target
Function
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.
Sequence similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
Contains 1 protein kinase domain.
Cellular localization
Nucleus.
Target information above from: UniProt accessionO00311
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Cdc 7 antibody
- CDC7 antibody
- CDC7 cell division cycle 7 antibody
see all
Database links
- Entrez Gene: 8317 Human
- Omim: 603311 Human
- SwissProt: O00311 Human
- Unigene: 28853 Human
- Unigene: 533573 Human
Anti-Cdc7 Kinase antibody [SPM171] images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cdc7 Kinase antibody [SPM171] (ab17880)
Immunohistochemistry on human tonsil using ab17880.
References for Anti-Cdc7 Kinase antibody [SPM171] (ab17880)
This product has been referenced in:
- Natoni Aet al. Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells. Mol Cancer Ther 10:1624-34 (2011).Read more (PubMed: 21768328) »
- Choschzick Met al. Overexpression of cell division cycle 7 homolog is associated with gene amplification frequency in breast cancer. Hum Pathol 41:358-65 (2010). IHC-P; Human.Read more (PubMed: 19896697) »
See all 2 publications for this product
Publishing research using ab17880? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"