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Product Name
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Cdc6 antibody [Cdc6 9H8/5]
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Cdc6 抗体 (9件) 一覧
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [Cdc6 9H8/5] to Cdc6
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Immunogen
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C terminal protein (Saccharomyces cerevisiae)
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Reacts with
(species key)
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Sc
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Tested applications
(see key)
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IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 58 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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The protein is nuclear in G1 and cytoplasmic in S-phase cells.
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Research areas
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Cell Biology >> Cell Cycle >> Cell Division >> Other cell division antibodies
Chromatin and Nuclear Signaling >> DNA / RNA >> DNA Synthesis >> Other
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Relevance
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Cell cycle events are regulated by the sequential activation and deactivation of cyclin depended kinase (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc6 is essential for assembling the pre-replicative complex that forms at origins of DNA replication in the G1 phase of the cell cycle in budding yeast (S. cerevisiae). Cdc6 is also involved in checkpoint controls that ensure that DNA replication is completed before initiation of mitosis.
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Cdc6 antibody [Cdc6 9H8/5] (ab20150)の別名 |
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Database links
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The links below go to external sites and will open in a new browser window SwissProt | | P09119 (Saccharomyces cerevisiae)
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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Cdc6 9H8/5
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Isotype
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IgG1
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Purity
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IgG fraction
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Storage buffer
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Preservative: None
Constituents: PBS
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Abcam では全ての製品情報を一元管理しており、 Cdc6 antibody [Cdc6 9H8/5] について私たちが知りうる全ての情報がこのデータシートでご覧いただけます。ご不明な点がありましたら、 お問い合わせください。 |
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References for Cdc6 antibody [Cdc6 9H8/5] (ab20150)
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This clone has been used in: (two most recent references)
Perkins G et al. Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis. EMBO J 20:4836-45 (2001). PubMed: 11532947
Donovan S et al. Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc Natl Acad Sci U S A 94:5611-6 (1997). PubMed: 9159120
If you publish research using ab20150 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to Cdc6
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Cdc6 antibody [Cdc6 9H8/5] - more information
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