Anti-Caveolin-1 (phospho Y14) 抗体 (ab38468)
Key features and details
- Rabbit polyclonal to Caveolin-1 (phospho Y14)
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Caveolin-1 (phospho Y14) antibody
Caveolin-1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Caveolin-1 (phospho Y14) -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse -
免疫原
Synthetic peptide corresponding to Human Caveolin-1 (phospho Y14).
Database link: Q03135 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 0.87% Sodium chloride, PBS
Without Mg2+ and Ca2+ -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab38468の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (1) |
1/500 - 1/1000. Detects a band of approximately 20 kDa (predicted molecular weight: 20 kDa).
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特記事項 |
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WB
1/500 - 1/1000. Detects a band of approximately 20 kDa (predicted molecular weight: 20 kDa). |
ターゲット情報
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機能
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. -
組織特異性
Expressed in muscle and lung, less so in liver, brain and kidney. -
関連疾患
Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. -
配列類似性
Belongs to the caveolin family. -
翻訳後修飾
The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated. -
細胞内局在
Golgi apparatus membrane. Cell membrane. Membrane > caveola. Membrane raft. Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. - Information by UniProt
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参照データベース
- Entrez Gene: 12389 Mouse
- SwissProt: P49817 Mouse
- Unigene: 28278 Mouse
- Unigene: 470537 Mouse
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別名
- BSCL3 antibody
- CAV antibody
- CAV1 antibody
see all
画像
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Lanes 1-2 : Caveolin-1 Antibody
Lanes 3-4 : Anti-Caveolin-1 (phospho Y14) antibody (ab38468) at 1/500 dilution
Lane 1 : NIH 3T3 cell extract
Lane 2 : NIH 3T3 cell extract. Pre-incubated with synthesized peptide
Lane 3 : NIH 3T3 cell extract.
Lane 4 : NIH 3T3 cell extract. Treated with H2O2.
Predicted band size: 20 kDa
Observed band size: 20 kDa
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab38468 は 1 報の論文で使用されています。
- Bracamontes CG et al. The serum protein profile of early parity which induces protection against breast cancer. Oncotarget 7:82538-82553 (2016). WB ; Human . PubMed: 27769065