製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to CYP2R1
  • アプリケーション
    適用あり: IHC-P, WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the C terminal region of human CYP2R1.

  • ポジティブ・コントロール
    • NCI-H460 cell line lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab80101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/10 - 1/50.
WB 1/50 - 1/100. Predicted molecular weight: 57 kDa.
ELISA 1/1000.

ターゲット情報

  • 機能
    Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).
  • 関連疾患
    Defects in CYP2R1 are the cause of rickets vitamin D-dependent type 1B (VDDR1B) [MIM:600081]; also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. A disorder caused by a selective deficiency of the active form of vitamin D (1,25-dihydroxyvitamin D3) and resulting in defective bone mineralization and clinical features of rickets. The patients sera have low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activityand low levels of 25-hydroxyvitamin D.
  • 配列類似性
    Belongs to the cytochrome P450 family.
  • 細胞内局在
    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CP2R1_HUMAN antibody
    • CYP2R1 antibody
    • Cytochrome P450 2R1 antibody
    • Cytochrome P450 family 2 R1 antibody
    • Cytochrome P450 family 2 subfamily R polypeptide 1 antibody
    • EC 1.14.13.15 antibody
    • MGC4663 antibody
    • Vitamin D 25 hydroxylase antibody
    • Vitamin D 25-hydroxylase antibody
    see all

画像

  • Anti-CYP2R1 antibody (ab80101) at 1/50 dilution + NCI-H460 cell line lysates at 35 µg

    Predicted band size : 57 kDa
    Observed band size : 64 kDa (why is the actual band size different from the predicted?)
  • ab80101 at 1/50 dilution staining CYP2R1 in human brain tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections). A peroxidase conjugated secondary antibody was used followed by DAB staining.

参考文献

This product has been referenced in:
  • O'Shaughnessy PJ  et al. Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver. J Clin Endocrinol Metab 96:2851-60 (2011). WB ; Human . Read more (PubMed: 21715529) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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