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Products:Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Overview
Product name
Anti-CRMP4 antibody
CRMP4 抗体 (4件) 一覧
Description
Rabbit polyclonal to CRMP4
Specificity
CRMP4 protein (Ulip1/TUC4). This antibody has been reported to label early postmitotic neurons in prenatal rat brain. The antibody is not reactive with the proteins TUC-1 (Ulip3/CRMP1), TUC2 (Ulip2/CRMP2) or TUC3 (Ulip4/CRMP3). It does not label neural progenitor or radial glia.
Tested applications
ICC, WB, IP, IHC-FoFrmore details
Cross reactivity
Reacts with
Mouse, Rat, Cat, Human, Monkey
Immunogen
Synthetic peptide: YDGPVFDLTT TPK, corresponding to C terminal amino acids 499-511 of Human CRMP4
YDGPVFDLTT TPK
Positive control
Mainly in heart and skeletal muscle. Also expressed strongly in fetal brain and spinal cord.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.2% Sodium Azide
Constituents: Whole serum
Purity
Whole antiserum
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Neurology process >> Neurogenesis
Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Applications
Show applications key
Our Abpromise guarantee covers the use of ab23951 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC
WB
IP
IHC-FoFr
Application notes
ICC: 1/5000 - 1/10000 (DAB detection).
IHC-Fo: 1/5000 - 1/10000 using PFA (DAB detection).
IP: Use at an assay dependent dilution.
WB: 1/10000 - 1/100000 using alkaline phosphatase. Predicted molecular weight: 62 kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
The collapsin response mediator protein (CRMP) family of five cytosolic phosphoproteins are highly expressed throughout brain development. The functions of CRMPs encompass signal transduction in developmental guidance cues as well as multiple cellular and molecular events involved in apoptosis/proliferation, cell migration, and differentiation. In the adult brain, the expression of CRMPs is dramatically downregulated. However, CRMPs remain expressed in structures that retain their capacity for differentiation and plasticity. The expression of CRMPs is altered in neurodegenerative diseases, and these proteins may have a role in the physiopathology of the adult nervous system.
Cellular localization
Cytoplasmic. Cell projection, growth cone (By similarity). Note: Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
Alternative names
- Unc 33 like phosphoprotein antibody
- Collapsin response mediator protein 4 antibody
- Collapsin response mediator protein 4 long antibody
see all
Database links
- Entrez Gene: 1809 Human
- Entrez Gene: 22240 Mouse
- Entrez Gene: 25418 Rat
- Omim: 601168 Human
- SwissProt: Q14195 Human
- SwissProt: Q62188 Mouse
- SwissProt: Q62952 Rat
- Unigene: 519659 Human
see all
References for Anti-CRMP4 antibody (ab23951)
This product has been referenced in:
- Yocum AKet al. Coupled global and targeted proteomics of human embryonic stem cells during induced differentiation. Mol Cell Proteomics 7:750-67 (2008).Read more (PubMed: 18304949) »
- Gramolini AOet al. Comparative proteomic profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses. Mol Cell Proteomics : (2007). WB; Mouse.Read more (PubMed: 18056057) »
See all 2 publications for this product
Publishing research using ab23951? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"