Anti-CSN7A 抗体 [EPR6463] (ab124705)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR6463] to CSN7A
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
製品の概要
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製品名
Anti-CSN7A antibody [EPR6463]
CSN7A 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EPR6463] to CSN7A -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details
適用なし: Flow Cyt,ICC/IF,IHC-P or IP -
種交差性
交差種: Human
交差が予測される動物種: Rat -
免疫原
Synthetic peptide corresponding to Human CSN7A aa 200-300.
Database link: Q9UBW8 -
ポジティブ・コントロール
- HeLa, JAR, human fetal muscle, brain, heart, and kidney lysates.
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特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
解離定数(KD 値)
KD = 1.35 x 10 -10 M Learn more about KD -
バッファー
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EPR6463 -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab124705の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 30 kDa.
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特記事項 |
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WB
1/1000 - 1/10000. Predicted molecular weight: 30 kDa. |
ターゲット情報
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機能
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. -
組織特異性
Widely expressed. Expressed at high level in brain, heart and skeletal muscle. -
配列類似性
Belongs to the CSN7/EIF3M family. CSN7 subfamily.
Contains 1 PCI domain. -
翻訳後修飾
Phosphorylated by CK2 and PKD kinases. -
細胞内局在
Cytoplasm. Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 50813 Human
- Entrez Gene: 312710 Rat
- SwissProt: Q9UBW8 Human
- Unigene: 530823 Human
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別名
- COP9 complex subunit 7a antibody
- COP9 constitutive photomorphogenic homolog subunit 7A antibody
- COP9 signalosome complex subunit 7a antibody
see all
画像
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All lanes : Anti-CSN7A antibody [EPR6463] (ab124705) at 1/1000 dilution
Lane 1 : HeLa cell lysate
Lane 2 : JAR cell lysate
Lane 3 : Human fetal muscle cell lysate
Lane 4 : Human brain cell lysate
Lane 5 : Human heart cell lysate
Lane 6 : Human kidney cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 30 kDa
Standard HRP labelled goat anti-rabbit at 1:2000.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab124705 は論文での使用が確認できていません。