CGP 55845 hydrochloride, GABAB antagonist (ab120337)
Key features and details
- Potent, selective GABAB antagonist
- CAS Number: 149184-22-5
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
-
製品名
CGP 55845 hydrochloride, GABAB antagonist -
製品の詳細
Potent, selective GABAB antagonist -
別名
- CGP55845 hydrochloride
-
CAS 番号
149184-22-5 -
構造式
製品の特性
-
体系名
[(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride -
分子量
438.72 -
分子式
C18H22Cl2NO3P.HCl -
PubChem 登録番号
9954841 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES 線形表記
C[C@@H](C1=CC(=C(C=C1)Cl)Cl)NC[C@@H](CP(=O)(CC2=CC=CC=C2)O)O.Cl -
由来
Synthetic
-
研究分野
画像
-
2D chemical structure image of ab120337, CGP 55845 hydrochloride, GABAB antagonist
-
5-CT-activated inwardly rectifying K+ conductance in 5-HT neurons displays limited desensitization.
(A) Time-course of a representative experiment (n = 6) showing the effect of increasing concentrations of bath applied 5-HT1A receptor agonist, 5-CT on inwardly rectifying K+ conductance (G-110/-90 mV) in a dorsal raphe 5-HT neuron. Extracellular solution contained 5.5 mM K+ and a mix of synaptic blockers (including ab120337). In this Fig time indicates duration of whole-cell configuration.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (31)
ab120337 は 31 報の論文で使用されています。
- Mishra P & Narayanan R Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells. iScience 25:103922 (2022). PubMed: 35252816
- Dai KZ et al. Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward. Cell Rep 40:111440 (2022). PubMed: 36170833
- Zhang J et al. Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice. Cell Rep 36:109495 (2021). PubMed: 34348148
- Booker SA et al. Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network. Elife 9:N/A (2020). PubMed: 32073397
- Chittajallu R et al. Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells. Elife 9:N/A (2020). PubMed: 32496194