Anti-CEP135 抗体 (ab75005)
Key features and details
- Rabbit polyclonal to CEP135
- Suitable for: ELISA, ICC/IF, WB
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-CEP135 antibody -
製品の詳細
Rabbit polyclonal to CEP135 -
由来種
Rabbit -
アプリケーション
適用あり: ELISA, ICC/IF, WBmore details -
種交差性
交差種: Mouse, Human -
免疫原
synthesized peptide derived from C-terminal region of human CEP135.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Without Mg2+ and Ca2+ -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab75005の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration.
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ICC/IF | (1) |
Use at an assay dependent concentration.
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WB |
1/500 - 1/1000. Predicted molecular weight: 134 kDa.
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特記事項 |
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ELISA
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
WB
1/500 - 1/1000. Predicted molecular weight: 134 kDa. |
ターゲット情報
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機能
Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. -
関連疾患
Microcephaly 8, primary, autosomal recessive -
配列類似性
Belongs to the CEP135/TSGA10 family. -
細胞内局在
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles. - Information by UniProt
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参照データベース
- Entrez Gene: 9662 Human
- Entrez Gene: 381644 Mouse
- Omim: 611423 Human
- SwissProt: Q66GS9 Human
- SwissProt: Q6P5D4 Mouse
- Unigene: 518767 Human
- Unigene: 332452 Mouse
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別名
- centrosomal protein 135 kDa antibody
- centrosomal protein 135kDa antibody
- Centrosomal protein 4 antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (35)
ab75005 は 35 報の論文で使用されています。
- Bühler M et al. GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells. Life Sci Alliance 6:N/A (2023). PubMed: 36384894
- Magistrati E et al. Myosin VI regulates ciliogenesis by promoting the turnover of the centrosomal/satellite protein OFD1. EMBO Rep 23:e54160 (2022). PubMed: 34957672
- Chu Z & Gruss OJ Mitotic Maturation Compensates for Premature Centrosome Splitting and PCM Loss in Human cep135 Knockout Cells. Cells 11:N/A (2022). PubMed: 35406752
- Tátrai P & Gergely F Centrosome function is critical during terminal erythroid differentiation. EMBO J 41:e108739 (2022). PubMed: 35678476
- Mahen R cNap1 bridges centriole contact sites to maintain centrosome cohesion. PLoS Biol 20:e3001854 (2022). PubMed: 36282799