Anti-CD8 alpha 抗体 [CA9.JD3] (ab34105)
Key features and details
- Mouse monoclonal [CA9.JD3] to CD8 alpha
- Suitable for: IHC-Fr, IP, Flow Cyt
- Reacts with: Dog
- Isotype: IgG2a
製品の概要
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製品名
Anti-CD8 alpha antibody [CA9.JD3]
CD8 alpha 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [CA9.JD3] to CD8 alpha -
由来種
Mouse -
特異性
Recognizes canine homologue CD8 alpha chain which is expressed by a thymocytes, peripheral T cells and a splenic zone macrophages. -
アプリケーション
適用あり: IHC-Fr, IP, Flow Cytmore details -
種交差性
交差種: Dog -
免疫原
Tissue, cells or virus corresponding to Dog CD8 alpha. Dog thymocytes
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ポジティブ・コントロール
- Spleen, lymphnode
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特記事項
Clone CA9.JD3 has been reported to inhibit cytotoxic T lymphocyte function. Removal of sodium azide is recommended prior to use in functional assays.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
Preservative: 0.09% Sodium azide
Constituent: Tissue culture supernatant -
Concentration information loading...
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精製度
Tissue culture supernatant -
一次抗体 備考
Clone CA9.JD3 has been reported to inhibit cytotoxic T lymphocyte function. Removal of sodium azide is recommended prior to use in functional assays. -
ポリ/モノ
モノクローナル -
クローン名
CA9.JD3 -
ミエローマ
P3x63-Ag8.653 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab34105の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-Fr |
Use at an assay dependent concentration.
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IP |
Use at an assay dependent concentration.
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|
Flow Cyt |
Use at an assay dependent concentration.
ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
特記事項 |
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IHC-Fr
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
ターゲット情報
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機能
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. -
関連疾患
Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. -
配列類似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
翻訳後修飾
All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
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別名
- alpha polypeptide (p32) antibody
- CD_antigen=CD8a antibody
- CD8 antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (2)
ab34105 は 2 報の論文で使用されています。
- Cobbold S & Metcalfe S Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens 43:137-54 (1994). PubMed: 8091414
- Moore PF et al. Monoclonal antibodies specific for canine CD4 and CD8 define functional T-lymphocyte subsets and high-density expression of CD4 by canine neutrophils. Tissue Antigens 40:75-85 (1992). PubMed: 1412420