PE Anti-CD24 抗体 [SN3] (ab77219)
Key features and details
- PE Mouse monoclonal [SN3] to CD24
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG1
Related conjugates and formulations
製品の概要
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製品名
PE Anti-CD24 antibody [SN3]
CD24 一次抗体 製品一覧 -
製品の詳細
PE Mouse monoclonal [SN3] to CD24 -
由来種
Mouse -
標識
PE. Ex: 488nm, Em: 575nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Human -
免疫原
Tissue, cells or virus corresponding to Human CD24. Glycoproteins purified from human NALM-1 cell line
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ポジティブ・コントロール
- Human blood cells.
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特記事項
Purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.4
Preservative: 0.097% Sodium azide
Constituent: 0.2% BSA
0.2% (w/v) high-grade protease free BSA -
Concentration information loading...
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精製度
Size exclusion -
ポリ/モノ
モノクローナル -
クローン名
SN3 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Alternative Versions
- Anti-CD24 antibody [SN3] (ab134375)
- APC/Cy7® Anti-CD24 antibody [SN3], prediluted (ab197137)
- APC Anti-CD24 antibody [SN3] (ab239286)
- PerCP/Cy5.5® Anti-CD24 antibody [SN3] (ab239339)
- Alexa Fluor® 700 Anti-CD24 antibody [SN3] (ab269310)
- FITC Anti-CD24 antibody [SN3] (ab30350)
- PE Anti-CD24 antibody [SN3], prediluted (ab30351)
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab77219の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Flow Cyt | (1) |
Use 20µl for 106 cells.
ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 20µl per 100µl of whole blood or 106 cells in suspension. |
特記事項 |
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Flow Cyt
Use 20µl for 106 cells. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 20µl per 100µl of whole blood or 106 cells in suspension. |
ターゲット情報
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機能
Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. -
組織特異性
B-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. -
関連疾患
Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface. -
配列類似性
Belongs to the CD24 family. -
翻訳後修飾
Extensively O-glycosylated. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 100133941 Human
- Omim: 600074 Human
- SwissProt: P25063 Human
- Unigene: 644105 Human
- Unigene: 721443 Human
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別名
- CD 24 antibody
- CD24 antibody
- CD24 antigen (small cell lung carcinoma cluster 4 antigen) antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (11)
ab77219 は 11 報の論文で使用されています。
- Yang XL et al. microRNA-873 inhibits self-renewal and proliferation of pancreatic cancer stem cells through pleckstrin-2-dependent PI3K/AKT pathway. Cell Signal 84:110025 (2021). PubMed: 33915247
- Weinberg F et al. EGFR Expression in HER2-Driven Breast Cancer Cells. Int J Mol Sci 21:N/A (2020). PubMed: 33260837
- Quayle LA et al. Chemotherapy resistance and stemness in mitotically quiescent human breast cancer cells identified by fluorescent dye retention. Clin Exp Metastasis 35:831-846 (2018). PubMed: 30377878
- Peckys DB et al. Liquid-phase electron microscopy of molecular drug response in breast cancer cells reveals irresponsive cell subpopulations related to lack of HER2 homodimers. Mol Biol Cell N/A:N/A (2017). PubMed: 28794264
- Sagara A et al. Intrinsic Resistance to 5-Fluorouracil in a Brain Metastatic Variant of Human Breast Cancer Cell Line, MDA-MB-231BR. PLoS One 11:e0164250 (2016). PubMed: 27723829