APC/Cy7® Anti-CD11b 抗体 [ICRF44] (ab197129)
Key features and details
- APC/Cy7® Mouse monoclonal [ICRF44] to CD11b
- Suitable for: Flow Cyt
- Reacts with: Human, Non human primates
- Conjugation: APC/Cy7®. Ex: 650nm, Em: 774nm
- Isotype: IgG1
Related conjugates and formulations
製品の概要
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製品名
APC/Cy7® Anti-CD11b antibody [ICRF44]
CD11b 一次抗体 製品一覧 -
製品の詳細
APC/Cy7® Mouse monoclonal [ICRF44] to CD11b -
由来種
Mouse -
標識
APC/Cy7®. Ex: 650nm, Em: 774nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Human, Non human primates -
免疫原
Tissue, cells or virus corresponding to Human CD11b. (Rheumatoid synovial cells and Human monocytes).
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ポジティブ・コントロール
- Flow cyt: Human peripheral blood.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. Store In the Dark. -
バッファー
pH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 99% PBS, 0.2% BSA
High-grade protease free BSA -
Concentration information loading...
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精製度
Size exclusion -
ポリ/モノ
モノクローナル -
クローン名
ICRF44 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Alternative Versions
- PE/Cy7® Anti-CD11b antibody [ICRF44], prediluted (ab135929)
- FITC Anti-CD11b antibody [ICRF44] (ab176541)
- Alexa Fluor® 488 Anti-CD11b antibody [ICRF44], prediluted (ab187597)
- APC Anti-CD11b antibody [ICRF44] (ab218639)
- Biotin Anti-CD11b antibody [ICRF44] (ab239235)
- FITC Anti-CD11b antibody [ICRF44] (ab269333)
- PE/Cy7® Anti-CD11b antibody [ICRF44] (ab269334)
- Anti-CD11b antibody [ICRF44] (ab34216)
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab197129の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
Flow Cyt |
Use 4µl for 106 cells.
or 4µl/100 µl whole blood |
特記事項 |
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Flow Cyt
Use 4µl for 106 cells. or 4µl/100 µl whole blood |
ターゲット情報
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機能
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. -
組織特異性
Predominantly expressed in monocytes and granulocytes. -
関連疾患
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. -
配列類似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
ドメイン
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 3684 Human
- Omim: 120980 Human
- SwissProt: P11215 Human
- Unigene: 172631 Human
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別名
- antigen CD11b (p170) antibody
- Antigen CD11b p170 antibody
- CD11 antigen like family member B antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (0)
ab197129 は論文での使用が確認できていません。