製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to CARD12
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: WB, IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to amino acids near the C-terminus of Human CARD12.

  • ポジティブ・コントロール
    • Human Brain, Cortex tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab115537 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 114 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Plays a role in the promotion of apoptosis.
  • 組織特異性
    Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.
  • 配列類似性
    Contains 1 CARD domain.
    Contains 14 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • 細胞内局在
    Cytoplasm. Cytoplasmic filaments.
  • Information by UniProt
  • 参照データベース
  • 別名
    • and NACHT-containing protein antibody
    • CARD 12 antibody
    • CARD antibody
    • CARD LRR and NACHT containing protein 1 antibody
    • CARD LRR and NACHT containing protein antibody
    • CARD12 antibody
    • Caspase recruitment domain containing protein 12 antibody
    • Caspase recruitment domain family member 12 antibody
    • Caspase recruitment domain-containing protein 12 antibody
    • CLAN 1 antibody
    • CLAN A antibody
    • CLAN antibody
    • CLAN B antibody
    • CLAN C antibody
    • CLAN D antibody
    • Clan protein antibody
    • CLAN1 antibody
    • CLANA antibody
    • CLANB antibody
    • CLANC antibody
    • CLAND antibody
    • CLR 2.1 antibody
    • CLR2.1 antibody
    • ICE protease activating factor antibody
    • Ice protease-activating factor antibody
    • Ipaf antibody
    • LRR antibody
    • NLR family CARD domain containing 4 antibody
    • NLR family CARD domain-containing protein 4 antibody
    • NLRC 4 antibody
    • NLRC4 antibody
    • NLRC4_HUMAN antibody
    • NOD like receptor C4 antibody
    • Nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 4 antibody
    • UNQ6189/PRO20215 antibody
    see all

画像

  • Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with ab115537 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

参考文献

This product has been referenced in:
  • Furman D  et al. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nat Med 23:174-184 (2017). Read more (PubMed: 28092664) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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