Anti-C1s 抗体 [M81] (ab81707)
Key features and details
- Mouse monoclonal [M81] to C1s
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
製品の概要
-
製品名
Anti-C1s antibody [M81]
C1s 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [M81] to C1s -
由来種
Mouse -
特異性
ab81707 reacts around the binding site of C1s and reacts with both active and inactive C1s. -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
The details of the immunogen for this antibody are not available.
-
エピトープ
ab81707 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). The epitope recognized by ab81707 is domain IV and/or V of the gamma domain of activated C1s. -
ポジティブ・コントロール
- IHC-P: Human liver melanoma cells.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Constituents: 0.1% BSA, PBS -
Concentration information loading...
-
特記事項(精製)
ab81707 is a purified, 0.2 µm filtered solution. -
ポリ/モノ
モノクローナル -
クローン名
M81 -
アイソタイプ
IgG1 -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab81707の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P | (1) |
Use at an assay dependent concentration.
|
特記事項 |
---|
IHC-P
Use at an assay dependent concentration. |
ターゲット情報
-
機能
C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. -
関連疾患
Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:613783]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. -
配列類似性
Belongs to the peptidase S1 family.
Contains 2 CUB domains.
Contains 1 EGF-like domain.
Contains 1 peptidase S1 domain.
Contains 2 Sushi (CCP/SCR) domains. -
翻訳後修飾
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. - Information by UniProt
-
参照データベース
- Entrez Gene: 716 Human
- Omim: 120580 Human
- SwissProt: P09871 Human
- Unigene: 458355 Human
-
別名
- Basic proline rich peptide IB 1 antibody
- C1 esterase antibody
- C1S antibody
see all
画像
データシートおよび資料
-
Datasheet download
参考文献 (1)
ab81707 は 1 報の論文で使用されています。
- Matsumoto M et al. Probing the C4-binding site on C1s with monoclonal antibodies. Evidence for a C4/C4b-binding site on the gamma-domain. J Immunol 142:2743-50 (1989). PubMed: 2522968