Anti-Aquaporin 4 抗体 (ab125049)
Key features and details
- Rabbit polyclonal to Aquaporin 4
- Suitable for: ICC/IF, WB
- Reacts with: Rat
- Isotype: IgG
製品の概要
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製品名
Anti-Aquaporin 4 antibody
Aquaporin 4 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Aquaporin 4 -
由来種
Rabbit -
アプリケーション
適用あり: ICC/IF, WBmore details -
種交差性
交差種: Rat -
免疫原
Synthetic peptide:
N-CTKGSYMEVEDNRSQVETED
, corresponding to C terminal amino acids 273-291 of Rat Aquaporin 4 (NP_036957.1). -
ポジティブ・コントロール
- Rat kidney lysate; Rat kidney tissue
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20ºC. -
バッファー
Preservative: 0.09% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab125049の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
ICC/IF |
1/200 - 1/400.
|
|
WB |
1/1000 - 1/4000. Predicted molecular weight: 35 kDa.
|
特記事項 |
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ICC/IF
1/200 - 1/400. |
WB
1/1000 - 1/4000. Predicted molecular weight: 35 kDa. |
ターゲット情報
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機能
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. -
組織特異性
Brain - muscle >> heart, kidney, lung, and trachea. -
配列類似性
Belongs to the MIP/aquaporin (TC 1.A.8) family. -
ドメイン
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). -
翻訳後修飾
Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamats increases conductance by 40%. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 25293 Rat
- SwissProt: P47863 Rat
- Unigene: 90091 Rat
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別名
- AQP 4 antibody
- AQP-4 antibody
- AQP4 antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab125049 は 3 報の論文で使用されています。
- Sanches E et al. Dose-Dependent Neuroprotective Effects of Bovine Lactoferrin Following Neonatal Hypoxia-Ischemia in the Immature Rat Brain. Nutrients 13:N/A (2021). PubMed: 34836132
- Deng S et al. Relationship Between Pregnancy and Acute Disseminated Encephalomyelitis: A Single-Case Study. Front Immunol 11:609476 (2020). PubMed: 33597947
- Somers E et al. Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy. Ann Neurol 79:217-30 (2016). PubMed: 26506088