Anti-Activin Receptor Type IIA/ACVR2A 抗体 [EPR7407] (ab134082)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR7407] to Activin Receptor Type IIA/ACVR2A
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
製品の概要
-
製品名
Anti-Activin Receptor Type IIA/ACVR2A antibody [EPR7407]
Activin Receptor Type IIA/ACVR2A 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EPR7407] to Activin Receptor Type IIA/ACVR2A -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details
適用なし: Flow Cyt,ICC/IF,IHC-P or IP -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Synthetic peptide within Human Activin Receptor Type IIA/ACVR2A aa 1-100. The exact sequence is proprietary.
(Peptide available asab206674) -
ポジティブ・コントロール
- Human fetal liver, HepG2, HeLa, and K562 cell lysates.
-
特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
解離定数(KD 値)
KD = 4.37 x 10 -11 M Learn more about KD -
バッファー
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
-
精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EPR7407 -
アイソタイプ
IgG -
研究分野
関連製品
-
Alternative Versions
-
Isotype control
-
Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab134082の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
1/1000 - 1/10000. Detects a band of approximately 80 kDa (predicted molecular weight: 58 kDa).
|
特記事項 |
---|
WB
1/1000 - 1/10000. Detects a band of approximately 80 kDa (predicted molecular weight: 58 kDa). |
ターゲット情報
-
機能
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. -
配列類似性
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 protein kinase domain. -
細胞内局在
Membrane. - Information by UniProt
-
参照データベース
- Entrez Gene: 92 Human
- Entrez Gene: 11480 Mouse
- Entrez Gene: 29263 Rat
- Omim: 102581 Human
- SwissProt: P27037 Human
- SwissProt: P27038 Mouse
- SwissProt: P38444 Rat
- Unigene: 470174 Human
see all -
別名
- Activin A receptor type IIA antibody
- Activin receptor type 2A antibody
- Activin receptor type IIA antibody
see all
画像
-
All lanes : Anti-Activin Receptor Type IIA/ACVR2A antibody [EPR7407] (ab134082) at 1/1000 dilution
Lane 1 : Human fetal liver lysate
Lane 2 : HepG2 cell lysate
Lane 3 : HeLa cell lysate
Lane 4 : K562 cell lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labelled Goat anti-rabbit at 1/2000 dilution
Predicted band size: 58 kDa
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (3)
ab134082 は 3 報の論文で使用されています。
- Werner CT et al. Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence. Proc Natl Acad Sci U S A 117:26460-26469 (2020). PubMed: 33020308
- Su X et al. Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development. Cell Death Dis 9:302 (2018). PubMed: 29467473
- Gancarz AM et al. Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity. Nat Neurosci : (2015). PubMed: 26030849