Anti-Activin A Receptor Type IB/ALK-4 抗体 [MM0054-11A7] (ab78415)
Key features and details
- Mouse monoclonal [MM0054-11A7] to Activin A Receptor Type IB/ALK-4
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-Activin A Receptor Type IB/ALK-4 antibody [MM0054-11A7]
Activin A Receptor Type IB/ALK-4 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [MM0054-11A7] to Activin A Receptor Type IB/ALK-4 -
由来種
Mouse -
特異性
ab78415 detects Activin A Receptor Type IB (ALK4). No cross reactivity was found to Activin A Receptor Type IA (ALK2). -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Recombinant fragment corresponding to Human Activin A Receptor Type IB/ALK-4 (extracellular).
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ポジティブ・コントロール
- WB: Human embryonic tissue lysate. IHC-P: Human placental tissue.
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特記事項
This antibody was produced from a hybridoma (mouse myeloma) fused with spleen cells from an immunized mouse.
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製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading...
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精製度
Protein G purified -
一次抗体 備考
This antibody was produced from a hybridoma (mouse myeloma) fused with spleen cells from an immunized mouse. -
ポリ/モノ
モノクローナル -
クローン名
MM0054-11A7 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab78415の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/100 - 1/1000. Predicted molecular weight: 57 kDa.
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IHC-P |
1/50.
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特記事項 |
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WB
1/100 - 1/1000. Predicted molecular weight: 57 kDa. |
IHC-P
1/50. |
ターゲット情報
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機能
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2. -
組織特異性
Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. -
配列類似性
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain. -
翻訳後修飾
Autophosphorylated. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 91 Human
- Omim: 601300 Human
- SwissProt: P36896 Human
- Unigene: 438918 Human
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製品の状態
There are 3 isoforms produced by alternative splicing. Isoform 1 also known as SKR2-1; isoform 2 as SKR2-2; isoform 3 as SKR2-3. -
別名
- Activin A receptor type 1B antibody
- Activin A receptor type II like kinase 4 antibody
- Activin A type 1B receptor antibody
see all
画像
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Anti-Activin A Receptor Type IB/ALK-4 antibody [MM0054-11A7] (ab78415) at 1/100 dilution + Human embryonic tissue lysate
Predicted band size: 57 kDa
Observed band size: 58 kDa why is the actual band size different from the predicted? -
ab78415 at 1/50 dilution, staining Activin A Receptor Type IB/ALK-4 in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).
データシートおよび資料
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Datasheet download
参考文献 (1)
ab78415 は 1 報の論文で使用されています。
- Tengroth L et al. Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps. Sci Rep 8:1561 (2018). PubMed: 29367682