Anti-ASXL1 抗体 [2049C2a] (ab50817)
Key features and details
- Mouse monoclonal [2049C2a] to ASXL1
- Suitable for: WB
- Reacts with: Recombinant fragment
- Isotype: IgG1
製品の概要
-
製品名
Anti-ASXL1 antibody [2049C2a]
ASXL1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [2049C2a] to ASXL1 -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Recombinant fragment -
免疫原
Recombinant fragment of ASXL1 (Human)
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at 4°C (stable for up to 12 months). Store at -20°C or -80°C. -
バッファー
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 1% BSA, PBS -
Concentration information loading...
-
精製度
Protein G purified -
特記事項(精製)
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. -
ポリ/モノ
モノクローナル -
クローン名
2049C2a -
アイソタイプ
IgG1 -
研究分野
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Co-activators/co-repressors
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab50817の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
Use at an assay dependent dilution. Predicted molecular weight: 165 kDa.
|
特記事項 |
---|
WB
Use at an assay dependent dilution. Predicted molecular weight: 165 kDa. |
ターゲット情報
-
機能
Probable Polycomb group (PcG) protein. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). -
組織特異性
Widely expressed at low level. Expressed in heart, brain, skeletal muscle, placenta, pancreas, spleen, prostate, small intestine, colon, peripheral blood, leukocytes, bone marrow and fetal liver. Highly expressed in testes. -
配列類似性
Belongs to the Asx family.
Contains 1 PHD-type zinc finger. -
ドメイン
Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which may be required for an association with nuclear receptors. -
細胞内局在
Nucleus. - Information by UniProt
-
別名
- Additional sex combs like 1 (Drosophila) antibody
- Additional sex combs like protein 1 antibody
- Additional sex combs-like protein 1 antibody
see all
画像
-
Anti-ASXL1 antibody [2049C2a] (ab50817) + Immunizing recombinant fragment
Predicted band size: 165 kDa
Observed band size: 39,43 kDa why is the actual band size different from the predicted?
データシートおよび資料
-
Datasheet download
参考文献 (1)
ab50817 は 1 報の論文で使用されています。
- Balasubramani A et al. Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex. Nat Commun 6:7307 (2015). WB ; Mouse . PubMed: 26095772