Anti-ARHGEF3 抗体 (ab136064)
Key features and details
- Rabbit polyclonal to ARHGEF3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-ARHGEF3 antibody
ARHGEF3 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to ARHGEF3 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Synthetic peptide derived from the C terminal region of Human ARHGEF3.
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ポジティブ・コントロール
- HeLa cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20ºC. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine)
PBS without Mg2+ and Ca2+ -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab136064の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 60 kDa.
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特記事項 |
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WB
1/500 - 1/1000. Predicted molecular weight: 60 kDa. |
ターゲット情報
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関連性
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. ARHGEF3 encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in ARHGEF3 plays a role in the determination of bone mineral density (BMD), suggesting a role in postmenopausal osteoporosis. -
細胞内局在
Cytoplasmic -
参照データベース
- Entrez Gene: 50650 Human
- Entrez Gene: 71704 Mouse
- Entrez Gene: 290541 Rat
- Omim: 612115 Human
- SwissProt: Q9NR81 Human
- SwissProt: Q91X46 Mouse
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別名
- 1200004I24Rik antibody
- 59.8 kDA protein antibody
- 9830169H03Rik antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab136064 は 1 報の論文で使用されています。
- Park J et al. Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E). Blood 130:1430-1440 (2017). PubMed: 28694326