Anti-AIM2 抗体 (ab93015)
Key features and details
- Rabbit polyclonal to AIM2
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
-
製品名
Anti-AIM2 antibody
AIM2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to AIM2 -
由来種
Rabbit -
アプリケーション
適用あり: ICC/IF, WB, IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse -
免疫原
Recombinant fragment, corresponding to amino acids 93-341 of Human AIM2 (NM_004833).
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Lyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
-
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab93015の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
ICC/IF |
Use at an assay dependent concentration.
|
|
WB | (4) |
1/500 - 1/1000. Predicted molecular weight: 39 kDa.
|
IHC-P | (1) |
1/100 - 1/500.
|
特記事項 |
---|
ICC/IF
Use at an assay dependent concentration. |
WB
1/500 - 1/1000. Predicted molecular weight: 39 kDa. |
IHC-P
1/100 - 1/500. |
ターゲット情報
-
機能
Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. -
組織特異性
Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. -
配列類似性
Belongs to the HIN-200 family.
Contains 1 DAPIN domain.
Contains 1 HIN-200 domain. -
細胞内局在
Nucleus. - Information by UniProt
-
参照データベース
- Entrez Gene: 9447 Human
- Entrez Gene: 383619 Mouse
- Omim: 604578 Human
- SwissProt: O14862 Human
- SwissProt: Q91VJ1 Mouse
- Unigene: 281898 Human
- Unigene: 131453 Mouse
-
別名
- Absent in melanoma 2 antibody
- AIM 2 antibody
- Aim2 antibody
see all
画像
-
All lanes : Anti-AIM2 antibody (ab93015) at 1/500 dilution
Lane 1 : EC-109 cell lysate
Lane 2 : HepG2 cell lysate
Predicted band size: 39 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of fetal spleen tissue sections labeling AIM2 with ab93015 at 1/100 dilution.
-
Immunohistochemical staining of AIM2 in formalin fixed, paraffin embedded Human fetal tonsil showing nuclear staining with ab93015 at a dilution of 1/100.
プロトコール
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (36)
ab93015 は 36 報の論文で使用されています。
- Li Z et al. Activation of the NLRP3 inflammasome and elevation of interleukin-1β secretion in infection by sever fever with thrombocytopenia syndrome virus. Sci Rep 12:2573 (2022). PubMed: 35173184
- Zhao Q et al. The central role of a two-way positive feedback pathway in molecular targeted therapies-mediated pyroptosis in anaplastic thyroid cancer. Clin Transl Med 12:e727 (2022). PubMed: 35184413
- Zhang T et al. CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition. Cell Death Dis 13:167 (2022). PubMed: 35190532
- Harkin K et al. Wedelolactone Attenuates N-methyl-N-nitrosourea-Induced Retinal Neurodegeneration through Suppression of the AIM2/CASP11 Pathway. Biomedicines 10:N/A (2022). PubMed: 35203520
- Zheng Y et al. Probenecid-Blocked Pannexin-1 Channel Protects Against Early Brain Injury via Inhibiting Neuronal AIM2 Inflammasome Activation After Subarachnoid Hemorrhage. Front Neurol 13:854671 (2022). PubMed: 35401398