Anti-ADAMTS6 抗体 (ab50647)
Key features and details
- Rabbit polyclonal to ADAMTS6
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-ADAMTS6 antibody
ADAMTS6 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to ADAMTS6 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Rat -
免疫原
A synthetic peptide based on the amino end of the catalytic domain of human ADAMTS-6.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: PBS, 50% Glycerol, 2.9% Sodium chloride -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab50647の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/1000. Predicted molecular weight: 97 kDa.
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特記事項 |
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WB
1/1000. Predicted molecular weight: 97 kDa. |
ターゲット情報
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組織特異性
Expressed at low levels in placenta and barely detectable in a number of other tissues. -
配列類似性
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 1 PLAC domain.
Contains 5 TSP type-1 domains. -
ドメイン
The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. -
翻訳後修飾
The precursor is cleaved by a furin endopeptidase.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. -
細胞内局在
Secreted, extracellular space, extracellular matrix. - Information by UniProt
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参照データベース
- Entrez Gene: 11174 Human
- Entrez Gene: 361886 Rat
- Omim: 605008 Human
- SwissProt: Q9UKP5 Human
- Unigene: 482291 Human
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別名
- A disintegrin and metalloproteinase with thrombospondin motifs 6 antibody
- A Disintigrin And Metalloproteinase with ThromboSpondin motif 6 antibody
- ADAM-TS 6 antibody
see all
画像
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All lanes : Anti-ADAMTS6 antibody (ab50647) at 1/1000 dilution
Lane 1 : Cell media from human amnion-derived WISH cells (treated with IL1-beta) at 12 µl
Lane 2 : Cell media from human amnion-derived WISH cells (treated with IL1-beta) at 10 µl
Lane 3 : Cell media from human amnion-derived WISH cells (treated with IL1-beta) at 8 µl
Lane 4 : Cell media from human amnion-derived WISH cells (treated with IL1-beta) at 6 µl
Predicted band size: 97 kDa
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab50647 は 1 報の論文で使用されています。
- Turpeinen H et al. Identification of proprotein convertase substrates using genome-wide expression correlation analysis. BMC Genomics 12:618 (2011). WB ; Mouse . PubMed: 22185580