Anti-8 Hydroxyguanosine 抗体 (ab93295)

製品の概要

  • 製品名Anti-8 Hydroxyguanosine antibody
    8 Hydroxyguanosine 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to 8 Hydroxyguanosine
  • 特異性ab93295 detects 8 Hydroxyguanosine in synthetic or other in vitro samples.
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    Not applicable
  • 免疫原

    8 Hydroxyguanosine conjugate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: Whole serum
  • 精製度Whole antiserum
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab93295 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
IHC-P
  • 追加情報ELISA: 1/100000.
    IHC-P: 1/200.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 関連性8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer’s disease. 8OHdG has become increasing popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA. Biomonitoring in humans has demonstrated that 8OHdG can be excreted in the urine, and that a significant increase is caused by exposure to tobacco smoke and ionizing radiation. Because 8OHdG is so well correlated with oxidative stress and damage to DNA, which leads to degenerative disease states, the development of an antibody that can be used to study DNA damage has numerous applications. In addition to the direct study of DNA damage within cells, this antibody has applications in the development of immunoassays that can monitor 8OHdG excretion in the urine and serve as a biomarker of oxidative stress.
    • 別名
      • 8 hydroxy 2’ deoxyguanosine antibody
      • 8 hydroxyguanine antibody
      • 8 hydroxyguanosine antibody
      • 8 OHG antibody
      • 8-OHG antibody
      • 8OG antibody
      • 8OHdG antibody
      • 8OHG antibody
      see all

    Anti-8 Hydroxyguanosine antibody (ab93295) 使用論文

    ab93295 has not yet been referenced specifically in any publications.

    Product Wall

    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1µg/mL · Temperature: 25°C
    Antigen retrieval step Heat mediated
    Sample Mouse Tissue sections (Lung)
    Specification Lung
    Permeabilization Yes - 0.01% triton x
    Fixative Paraformaldehyde
    Username

    Abcam user community

    Verified customer

    投稿 Jul 29 2014

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"