製品の概要

  • 製品名
    8-Hydroxy-DPAT hydrobromide
  • 製品の詳細
    Standard selective 5-HT1a receptor agonist; affinity for 5-HT7 receptors
  • 生理活性の詳細
    Standard selective 5-HT1a receptor agonist. Moderate affinity for 5-HT7 receptors (pKi = 6.6) and able to antagonise 5-HT reuptake. Variety of biological effects seen in vivo.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Yelleswarapu NK  et al. Elucidating the role of 5-HT(1A) and 5-HT(7) receptors on 8-OH-DPAT-induced behavioral recovery after experimental traumatic brain injury. Neurosci Lett 515:153-6 (2012). Read more (PubMed: 22465320) »
  • Wood M  et al. Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT(7) receptor. Eur J Pharmacol 396:1-8 (2000). Read more (PubMed: 10822046) »
  • Assié MB & Koek W Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats. Br J Pharmacol 119:845-50 (1996). Read more (PubMed: 8922730) »
  • Gerber R  et al. Rotational behavior induced by 8-hydroxy-DPAT, a putative 5HT-1A agonist, in 6-hydroxydopamine-lesioned rats. Psychopharmacology (Berl) 94:178-82 (1988). Read more (PubMed: 2965396) »

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