Anti-68kDa Neurofilament/NF-L 抗体 (ab72997)
Key features and details
- Chicken polyclonal to 68kDa Neurofilament/NF-L
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgY
製品の概要
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製品名
Anti-68kDa Neurofilament/NF-L antibody
68kDa Neurofilament/NF-L 一次抗体 製品一覧 -
製品の詳細
Chicken polyclonal to 68kDa Neurofilament/NF-L -
由来種
Chicken -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Rat -
免疫原
Tissue, cells or virus corresponding to Cow 68kDa Neurofilament/NF-L. Bovine spinal cord intermediate filaments.
Database link: P02548 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.065% Sodium azide -
Concentration information loading...
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精製度
IgY fraction -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgY -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab72997の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (1) |
1/10000. Detects a band of approximately 68 kDa (predicted molecular weight: 61 kDa).
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特記事項 |
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WB
1/10000. Detects a band of approximately 68 kDa (predicted molecular weight: 61 kDa). |
ターゲット情報
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機能
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. -
関連疾患
Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F (CMT1F) [MIM:607734]. CMT1F is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1F is characterized by onset in infancy or childhood (range 1 to 13 years).
Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 2E (CMT2E) [MIM:607684]. CMT2E is an autosomal dominant form of Charcot-Marie-Tooth disease type 2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. -
配列類似性
Belongs to the intermediate filament family. -
ドメイン
The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions. -
翻訳後修飾
O-glycosylated.
Phosphorylated in the Head and Rod regions by the PKC kinase PKN1, leading to inhibit polymerization. - Information by UniProt
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参照データベース
- Entrez Gene: 83613 Rat
- SwissProt: P19527 Rat
- Unigene: 18568 Rat
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別名
- 68 kDa neurofilament protein antibody
- 68kDa Neurofilament antibody
- 68kDa neurofilament protein antibody
see all
画像
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Anti-68kDa Neurofilament/NF-L antibody (ab72997) at 1/10000 dilution + Rat cerebral cortex lysate
Predicted band size: 61 kDa
Observed band size: 68 kDa why is the actual band size different from the predicted?
データシートおよび資料
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Datasheet download
参考文献 (11)
ab72997 は 11 報の論文で使用されています。
- Gras S et al. Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system. Aging (Albany NY) 13:18051-18093 (2021). PubMed: 34319911
- Damián JP et al. Central Alteration in Peripheral Neuropathy of Trembler-J Mice: Hippocampal pmp22 Expression and Behavioral Profile in Anxiety Tests. Biomolecules 11:N/A (2021). PubMed: 33921657
- Kim B et al. Ontogeny of inter-alpha inhibitor protein (IAIP) expression in human brain. J Neurosci Res 98:869-887 (2020). PubMed: 31797408
- Blasco A et al. Motoneuron deafferentation and gliosis occur in association with neuromuscular regressive changes during ageing in mice. J Cachexia Sarcopenia Muscle 11:1628-1660 (2020). PubMed: 32691534
- Karbassi E et al. Direct visualization of cardiac transcription factories reveals regulatory principles of nuclear architecture during pathological remodeling. J Mol Cell Cardiol 128:198-211 (2019). PubMed: 30742811