製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 配列CLREQGRGKDQPGRL

関連製品

特性

Our Abpromise guarantee covers the use of ab45605 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-58K Golgi protein antibody (ab23932)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • Formimidoyltetrahydrofolate cyclodeaminase
    • Formimidoyltransferase cyclodeaminase
    • Formiminotetrahydrofolate cyclodeaminase
    • Formiminotransferase cyclodeaminase
    • Formiminotransferase-cyclodeaminase
    • FTCD
    • FTCD_HUMAN
    • Glutamate formiminotransferase
    • Glutamate formyltransferase
    • LCHC 1
    • LCHC1
    see all
  • 機能Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
    Binds and promotes bundling of vimentin filaments originating from the Golgi.
  • パスウェイAmino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.
    One-carbon metabolism; tetrahydrofolate interconversion.
  • 関連疾患Defects in FTCD are the cause of glutamate formiminotransferase deficiency (FIGLU-URIA) [MIM:229100]; also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.
  • 配列類似性In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.
    In the N-terminal section; belongs to the formiminotransferase family.
  • 細胞内局在Cytoplasm > cytoskeleton > centrosome > centriole. Golgi apparatus. More abundantly located around the mother centriole.
  • Information by UniProt

58K Golgi protein peptide (ab45605) 使用論文

ab45605 has not yet been referenced specifically in any publications.

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