製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to 53BP2/ASPP2
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region between residue 825 and 875 of human 53BP2/ASPP2 (NP_001026855.1)

  • ポジティブ・コントロール
    • Human prostate adenocarcinoma and mouse squamous cell carcinoma tissues.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab84996 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報
    IHC-P: 1/100 - 1/500.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
    • 組織特異性
      Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines.
    • 配列類似性
      Belongs to the ASPP family.
      Contains 2 ANK repeats.
      Contains 1 SH3 domain.
    • ドメイン
      The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53.
    • 細胞内局在
      Cytoplasm > perinuclear region. Nucleus. Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 53BP2 antibody
      • Apoptosis stimulating of p53 protein 2 antibody
      • Apoptosis stimulating protein of p53 2 antibody
      • Apoptosis-stimulating of p53 protein 2 antibody
      • ASPP2 antibody
      • ASPP2_HUMAN antibody
      • BBP antibody
      • Bcl2 binding protein antibody
      • Bcl2-binding protein antibody
      • NY REN 51 antigen antibody
      • p53 binding protein 2 antibody
      • p53-binding protein 2 antibody
      • p53BP2 antibody
      • PPP1R13A antibody
      • Renal carcinoma antigen NY-REN-51 antibody
      • Tp53bp2 antibody
      • Tumor protein p53 binding protein 2 antibody
      • Tumor suppressor p53 binding protein 2 antibody
      • Tumor suppressor p53-binding protein 2 antibody
      see all

    画像

    • ab84996 at 1/500 dilution staining 53BP2/ASPP2 in human prostate adenocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.
    • ab84996 at 1/100 dilution staining 53BP2/ASPP2 in mouse squamous cell carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    プロトコール

    参考文献

    ab84996 has not yet been referenced specifically in any publications.

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