製品の概要

  • 製品名Anti-53BP1 antibody
    53BP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to 53BP1
  • 特異性Detects endogenous levels of total 53BP1 protein
  • アプリケーション適用あり: ELISA, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic non-phosphopeptide derived from human 53BP1 around the phosphorylation site of serine 6

  • ポジティブ・コントロール
    • Hela cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab62626 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/10000.
ICC/IF 1/500 - 1/1000.

ターゲット情報

  • 機能May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.
  • 関連疾患Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
  • 配列類似性Contains 2 BRCT domains.
  • 翻訳後修飾Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.
    Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.
  • 細胞内局在Nucleus. Chromosome > centromere > kinetochore. Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 53 BP1 antibody
    • 53BP1 antibody
    • FLJ41424 antibody
    • MGC138366 antibody
    • p202 antibody
    • p53 binding protein 1 antibody
    • p53 BP1 antibody
    • p53-binding protein 1 antibody
    • p53BP1 antibody
    • TP53 BP1 antibody
    • TP53B_HUMAN antibody
    • Tp53bp1 antibody
    • TRP53 BP1 antibody
    • Tumor protein 53 binding protein 1 antibody
    • Tumor protein p53 binding protein 1 antibody
    • Tumor suppressor p53 binding protein 1 antibody
    • Tumor suppressor p53-binding protein 1 antibody
    see all

Anti-53BP1 antibody 画像

  • Immunofluorescence analysis of HeLa cells, using ab62626 at a 1/500-1/1000 dilution.

    Left image untreated.

    Right image treated with peptide.

Anti-53BP1 antibody (ab62626) 使用論文

ab62626 has not yet been referenced specifically in any publications.

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