Anti-53BP1 抗体 (ab36828)

製品の概要

• 製品名
  Anti-53BP1 antibody
  53BP1 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to 53BP1
• 特異性
  This antibody is specific for 53BP1 protein.
• アプリケーション
  適用あり: WB, ICC/IFmore details
• 種交差性
  交差種: Mouse, Human
  交差が予測される動物種: Rabbit, Horse, Cow, Dog, Chimpanzee, Baboon, Rhesus monkey, Gorilla, Chinese hamster, Orangutan
• 免疫原

  Synthetic peptide representing a portion of human 53BP1 encoded exon 19 (LocusLink ID 7158).

• ポジティブ･コントロール
  • U205, 293T and MO59K cell lysates (human). MEF lysates (mouse).

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  Preservative: 0.1% Sodium Azide
  Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8
• Concentration information loading...
• 精製度
  Protein A purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • DNA Damage Response
  • p53

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • DNA Damage Response
  • BRCT Domain Proteins

  • Cancer
  • Oncoproteins/suppressors
  • Tumor suppressors
  • p53 pathway

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能
  May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.
• 関連疾患
  Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
• 配列類似性
  Contains 2 BRCT domains.
• 翻訳後修飾
  Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.
  Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.
• 細胞内局在
  Nucleus. Chromosome > centromere > kinetochore. Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.

• Target information above from: UniProt accession Q12888 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 7158 Human
  • Entrez Gene: 27223 Mouse
  • Omim: 605230 Human
  • SwissProt: Q12888 Human
  • SwissProt: P70399 Mouse
  • Unigene: 440968 Human
  • Unigene: 383499 Mouse
  • Unigene: 481841 Mouse
• 別名
  • 53 BP1 antibody
  • 53BP1 antibody
  • FLJ41424 antibody

  • MGC138366 antibody
  • p202 antibody
  • p53 binding protein 1 antibody
  • p53 BP1 antibody
  • p53-binding protein 1 antibody
  • p53BP1 antibody
  • TP53 BP1 antibody
  • TP53B_HUMAN antibody
  • Tp53bp1 antibody
  • TRP53 BP1 antibody
  • Tumor protein 53 binding protein 1 antibody
  • Tumor protein p53 binding protein 1 antibody
  • Tumor suppressor p53 binding protein 1 antibody
  • Tumor suppressor p53-binding protein 1 antibody

  see all

プロトコール

• Western blot protocols
• Immunocytochemistry & immunofluorescence protocols