5-HT receptor agonist. Weak partial agonist at 5-HT3 (EC50 = 60 μM). (Ki values are 11 and 7.7 μM (as measured by inhibition of [3H] granisetron binding to 5-HT3A and 5-HT3AB receptors, respectively). Shows some selectivity for 5-HT2C over other 5-HT2 subtypes. 5-HT1C agonist.
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Bower KS et al. 5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function. Eur J Pharmacol580:291-7 (2008).
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Watts SW & Cohen ML Further evidence that the guinea pig tracheal contractile serotonergic receptor is a 5-hydroxytryptamine2 receptor: use of 5-methyltryptamine and dipropyl-5-carboxamidotryptamine. J Pharmacol Exp Ther264:271-5 (1993).
Read more (PubMed: 8423530) »