製品の概要

  • 製品名5-Iodo A85380 dihydrochloride
  • 製品の詳細
    Potent α4β2 and α6β2 receptor agonist
  • 生理活性の詳細Potent α4β2 and α6β2 receptor agonist (Ki = 0.2 nM at α4β2). 850 and 27000-fold more potent at α4β2 than α3β4 and α7, respectively. Shows antidepressant effects. Active in vivo.
  • 精製度> 98%

製品の特性

  • 体系名3-[(2S)-2-Azetidinylmethoxy]-5-iodopyridine dihydrochloride
  • 分子量363.03
  • 構造式Chemical Structure
  • 分子式C9H11IN2O.2HCl
  • CAS 番号1217837-17-6
  • 保存方法Store at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in water to 100 mM and DMSO to 100 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記Cl.Cl.Ic1cc(cnc1)OC[C@@H]2CCN2
  • 由来

    Synthetic

  • 研究分野

    5-Iodo A85380 dihydrochloride (ab120599) 使用論文

    This product has been referenced in:
    • Caldarone BJ  et al. Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380. Psychopharmacology (Berl) 217:199-210 (2011). Read more (PubMed: 21487659) »
    • Mogg AJ  et al. Functional responses and subunit composition of presynaptic nicotinic receptor subtypes explored using the novel agonist 5-iodo-A-85380. Neuropharmacology 47:848-59 (2004). Read more (PubMed: 15527819) »
    • Mukhin AG  et al. 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol 57:642-9 (2000). Read more (PubMed: 10692507) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"