Anti-5-Hydroxymethyluridine 抗体 (ab19735)
Key features and details
- Goat polyclonal to 5-Hydroxymethyluridine
- Suitable for: IP, ELISA
- Reacts with: Species independent
- Isotype: IgG
製品の概要
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製品名
Anti-5-Hydroxymethyluridine antibody -
製品の詳細
Goat polyclonal to 5-Hydroxymethyluridine -
由来種
Goat -
アプリケーション
適用あり: IP, ELISAmore details -
種交差性
交差種: Species independent -
免疫原
5-Hydroxymethyluridine coupled to a carrier protein.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.1% Sodium azide -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab19735の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IP |
Use at an assay dependent concentration. PubMed: 22514282
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ELISA |
1/25000.
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特記事項 |
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IP
Use at an assay dependent concentration. PubMed: 22514282 |
ELISA
1/25000. |
ターゲット情報
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関連性
5 Hydroxymethyluridine is formed from thymidine during the oxidation of DNA by ionizing radiation or reactive oxygen species (ROS) that are formed from inflammatory response. This causes genetic mutations, altered gene expression and chromosomal instability that has generally been implicated with aging, cancers and autoimmune disease. -
別名
- 5 HmdU antibody
- 5 Hydroxymethyl 2’ deoxyuridine antibody
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab19735 は 3 報の論文で使用されています。
- Herrmann A et al. Integrin a6 signaling induces STAT3-TET3-mediated hydroxymethylation of genes critical for maintenance of glioma stem cells. Oncogene 39:2156-2169 (2020). PubMed: 31819166
- Yakovlev IA et al. Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome. Sci Rep 9:19314 (2019). PubMed: 31848418
- Cliffe LJ et al. JBP1 and 2 are Fe2+/2-OG dependent dioxygenases regulating the hydroxylation of thymidine residues in trypanosome DNA. J Biol Chem : (2012). IP . PubMed: 22514282