製品の概要

  • 製品名
    4-Oxo-2-nonenal (4-ONE)
  • 製品の詳細
    Lipid peroxidation product. TRPA1 activator.
  • 別名
    • 4-ONE
  • 生理活性の詳細
    Lipid peroxidation product, actively modifies histidine and lysine residues on proteins and causes protein cross-linking. Shows a variety of biological activities and is a TRPA1 activator (EC50 = 1.9 µM). Active in vivo.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Näsström T  et al. The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of a-synuclein oligomers with distinct biochemical, morphological, and functional properties. Free Radic Biol Med 50:428-37 (2011). Read more (PubMed: 21130160) »
  • Graepel R  et al. 4-oxo-2-nonenal (4-ONE): evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo. J Pharmacol Exp Ther 337:117-24 (2011). Read more (PubMed: 21205926) »
  • Lee SH & Blair IA Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation. Chem Res Toxicol 13:698-702 (2000). Read more (PubMed: 10956056) »

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