4-Aminopyridine (4-AP), K+ channel blocker (ab120122)
Key features and details
- K+ channel blocker
- CAS Number: 504-24-5
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
4-Aminopyridine (4-AP), K+ channel blocker -
製品の詳細
K+ channel blocker -
別名
- 4-AP
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生理活性の詳細
Potassium channel blocker. Blocks Kv channels. Convulsant, and useful tool to model epileptiform activity in vitro.
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CAS 番号
504-24-5 -
構造式
製品の特性
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体系名
4-Aminopyridine -
分子量
94.12 -
分子式
C5H6N2 -
PubChem 登録番号
1727 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Nc1ccncc1 -
由来
Synthetic
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研究分野
画像
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2D chemical structure image of ab120122, 4-Aminopyridine (4-AP), K+ channel blocker
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4-AP-induced LFPs provoke AP firing from SST-interneurons. Representative images of GCaMP3 signal in a visual field containing several SST interneurons before (left) and during (right) LFPP-CA3/DG (induced with 4-AP).
Grosser S et al., PloS one., 9(1): e86250. Fig 3A.; doi: 10.1371/journal.pone.0086250
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (11)
ab120122 は 11 報の論文で使用されています。
- Yu W et al. Periaqueductal gray/dorsal raphe dopamine neurons contribute to sex differences in pain-related behaviors. Neuron 109:1365-1380.e5 (2021). PubMed: 33740416
- Liu BH et al. Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour. Nature 538:383-387 (2016). PubMed: 27732573
- Grosser S et al. Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model. PLoS One 9:e86250 (2014). PubMed: 24465989
- Chiavegato A et al. The inflammatory molecules IL-1ß and HMGB1 can rapidly enhance focal seizure generation in a brain slice model of temporal lobe epilepsy. Front Cell Neurosci 8:155 (2014). PubMed: 24936172
- Arruda-Carvalho M & Clem RL Pathway-selective adjustment of prefrontal-amygdala transmission during fear encoding. J Neurosci 34:15601-9 (2014). PubMed: 25411488