製品の概要

  • 製品名3-Methyladenine
  • 製品の詳細
    Selective PI3K inhibitor
  • 生理活性の詳細Selective PI3K inhibitor. Inhibits the initial phase of the autophagy. Blocks autophagosome formation. Potentiates apoptosis. Inhibits protein degradation (IC50 = 5 mM, rat hepatocytes).
  • 精製度> 98%

製品の特性

    3-Methyladenine (ab120841) 使用論文

    This product has been referenced in:
    • Tran AT  et al. Autophagy inhibitor 3-methyladenine potentiates apoptosis induced by dietary tocotrienols in breast cancer cells. Eur J Nutr 54:265-72 (2015). Read more (PubMed: 24830781) »
    • Pliyev BK & Menshikov M Differential effects of the autophagy inhibitors 3-methyladenine and chloroquine on spontaneous and TNF-a-induced neutrophil apoptosis. Apoptosis 17:1050-65 (2012). Read more (PubMed: 22638980) »
    • Viola G  et al. MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochem Pharmacol 83:16-26 (2012). Read more (PubMed: 21964343) »
    • Wu YT  et al. Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem 285:10850-61 (2010). Read more (PubMed: 20123989) »
    • Seglen PO & Gordon PB 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A 79:1889-92 (1982). Read more (PubMed: 6952238) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120841.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"