製品の概要

  • 製品名
    3-Methyladenine
  • 製品の詳細
    Selective PI3K inhibitor
  • 生理活性の詳細
    Selective PI3K inhibitor. Inhibits the initial phase of the autophagy. Blocks autophagosome formation. Potentiates apoptosis. Inhibits protein degradation (IC50 = 5 mM, rat hepatocytes).
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Tran AT  et al. Autophagy inhibitor 3-methyladenine potentiates apoptosis induced by dietary tocotrienols in breast cancer cells. Eur J Nutr 54:265-72 (2015). Read more (PubMed: 24830781) »
  • Pliyev BK & Menshikov M Differential effects of the autophagy inhibitors 3-methyladenine and chloroquine on spontaneous and TNF-a-induced neutrophil apoptosis. Apoptosis 17:1050-65 (2012). Read more (PubMed: 22638980) »
  • Viola G  et al. MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochem Pharmacol 83:16-26 (2012). Read more (PubMed: 21964343) »
  • Wu YT  et al. Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem 285:10850-61 (2010). Read more (PubMed: 20123989) »
  • Seglen PO & Gordon PB 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A 79:1889-92 (1982). Read more (PubMed: 6952238) »

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