製品の概要

  • 製品名2-Furoyl-LIGRLO-amide (2Fly)
  • 製品の詳細
    Potent and selective PAR2 agonist
  • 別名
    • 2Fly
  • 生理活性の詳細Potent and selective PAR2 receptor agonist (EC50 = 340 nM). Induces arterial contraction. Facilitates capsaicin evoked nociception. Around 100 times more potent than SLIGR-NH2 (ab120176).
  • 精製度> 95%

製品の特性

  • 分子量777.96
  • 構造式Chemical Structure
  • 分子式C36H63N11O8
  • CAS 番号729589-58-6
  • 配列LIGRLX (Modifications: N-terminal 2-Furoyl; C-terminal amide; X-6 = Orn)
  • 保存方法Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in water to 1 mg/ml
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 由来

    Synthetic

  • 研究分野

    2-Furoyl-LIGRLO-amide (2Fly) (ab120800) 使用論文

    This product has been referenced in:
    • Hollenberg MD  et al. Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization. J Pharmacol Exp Ther 326:453-62 (2008). Read more (PubMed: 18477767) »
    • Saifeddine M  et al. Proteinase-activated receptor-2 activating peptides: distinct canine coronary artery receptor systems. Am J Physiol Heart Circ Physiol 293:H3279-89 (2007). Read more (PubMed: 17766477) »
    • Kawabata A  et al. Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: involvement of endogenous bradykinin. Neurosci Lett 402:167-72 (2006). Read more (PubMed: 16644120) »
    • McGuire JJ  et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther 309:1124-31 (2004). Read more (PubMed: 14976230) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"