製品の概要

  • 製品名2-Arachidonoyl glycerol-d8
  • 製品の詳細
    Potent, endogenous CB1 agonist
  • 生理活性の詳細Endogenous potent CB1 agonist (EC50 values are 519 and 618 nM at CB1 and CB2, respectively). Agonist activity also seen at GPR55 orphan receptor (EC50 = 3 nM). Able to induce a rapid and transient increases in intracellular Ca2+ concentrations in vitro. Abundantly expressed in the brain.
  • 精製度> 99%

法規制情報

製品の特性

    2-Arachidonoyl glycerol-d8 (ab120919) 使用論文

    This product has been referenced in:
    • Sugiura T  et al. Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. J Biol Chem 275:605-12 (2000). Read more (PubMed: 10617657) »
    • Sugiura T  et al. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. J Biol Chem 274:2794-801 (1999). Read more (PubMed: 9915812) »
    • Kondo S  et al. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through CA2+-dependent and -independent mechanisms. FEBS Lett 429:152-6 (1998). Read more (PubMed: 9650580) »

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