Endogenous potent CB1 agonist (EC50 values are 519 and 618 nM at CB1 and CB2, respectively). Agonist activity also seen at GPR55 orphan receptor (EC50 = 3 nM). Able to induce a rapid and transient increases in intracellular Ca2+ concentrations in vitro. Abundantly expressed in the brain.
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Sugiura T et al. Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. J Biol Chem275:605-12 (2000).
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Sugiura T et al. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. J Biol Chem274:2794-801 (1999).
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Kondo S et al. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through CA2+-dependent and -independent mechanisms. FEBS Lett429:152-6 (1998).
Read more (PubMed: 9650580) »