2-Methoxyantimycin A3, Bcl-xL and Bcl-2 inhibitor (ab141523)
Key features and details
- Bcl-xL and Bcl-2 inhibitor. Apoptotic.
- CAS Number:
- Purity: > 98%
- Soluble in DMSO to 10 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
2-Methoxyantimycin A3, Bcl-xL and Bcl-2 inhibitor -
製品の詳細
Bcl-xL and Bcl-2 inhibitor. Apoptotic. -
生理活性の詳細
Bcl-xL and Bcl-2 inhibitor. Antiapoptotic. Depolarizes mitochrondrial membrane potential. Reduces tumor size in vivo without toxicity. -
精製度
> 98% -
構造式
製品の特性
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体系名
2-Methoxyantimycin A3 -
分子量
534.60 -
分子式
C27H38N2O9 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 10 mM and in ethanol to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
O=CNc1cccc(c1OC)C(=O)N[C@@H]2C(=O)O[C@@H](C)[C@H](OC(=O)CC(C)C)[C@@H](CCCC)C(=O)O[C@@H]2C -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab141523 は 4 報の論文で使用されています。
- Wang Z et al. miRNA-93-5p in exosomes derived from M2 macrophages improves lipopolysaccharide-induced podocyte apoptosis by targeting Toll-like receptor 4. Bioengineered 13:7683-7696 (2022). PubMed: 35291915
- Osterlund EJ et al. Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells. Sci Adv 8:eabm7375 (2022). PubMed: 35442739
- Yang Z et al. CircPTK2 (hsa_circ_0003221) Contributes to Laryngeal Squamous Cell Carcinoma by the miR-1278/YAP1 Axis. J Oncol 2021:2408384 (2021). PubMed: 34691176
- Zhang D et al. Hepatoprotective effect of Xiayuxue decoction ethyl acetate fraction against carbon tetrachloride-induced liver fibrosis in mice via inducing apoptosis and suppressing activation of hepatic stellate cells. Pharm Biol 58:1229-1243 (2020). PubMed: 33332219