17beta-Estradiol, Selective agonist of ER receptor (ab120657)
Key features and details
- Selective agonist of ER receptor
- CAS Number: 50-28-2
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 75 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
17beta-Estradiol, Selective agonist of ER receptor -
製品の詳細
Selective agonist of ER receptor -
生理活性の詳細
Selective agonist of ER receptor. Binds to ERα and ERβ receptors (Ki values are 0.13 and 0.12 nM, respectively). Agonist at the GPR30 receptor, activates PI3K.
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精製度
> 99% -
CAS 番号
50-28-2 -
構造式
製品の特性
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体系名
17β-Estra-1,3,5(10)-triene-3,17-diol -
分子量
272.38 -
分子式
C18H24O2 -
PubChem 登録番号
5757 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 75 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
画像
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2D chemical structure image of ab120657, 17beta-Estradiol, Selective agonist of ER receptor
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ERα ligands regulate the expression of CLOCK at the transcription level.
Analysis of CLOCK mRNA levels in MCF-7 cells by real-time PCR. MCF-7 cells were cultured in phenol red free medium and charcoal striped FCS medium for 2 days before being treated with E2 and the expression of CLOCK was then analyzed by real-time PCR.
E2 = 17beta-Estradiol.
(From Figure 3A of Xiao et al).
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (18)
ab120657 は 18 報の論文で使用されています。
- He F et al. Necroptotic TNFα-Syndecan 4-TNFα Vicious Cycle as a Therapeutic Target for Preventing Temporomandibular Joint Osteoarthritis. J Bone Miner Res 37:1044-1055 (2022). PubMed: 35278225
- Ma Y et al. Low frequency pulsed electromagnetic fields exposure alleviate the abnormal subchondral bone remodeling at the early stage of temporomandibular joint osteoarthritis. BMC Musculoskelet Disord 23:987 (2022). PubMed: 36384557
- Alahmadi AA et al. Both Matricaria chamomilla and Metformin Extract Improved the Function and Histological Structure of Thyroid Gland in Polycystic Ovary Syndrome Rats through Antioxidant Mechanism. Biomolecules 10:N/A (2020). PubMed: 31948119
- Zha B et al. GPR30 Promotes the Phenotypic Switching of Vascular Smooth Muscle Cells via Activating the AKT and ERK Pathways. Onco Targets Ther 13:3801-3808 (2020). PubMed: 32440148
- Yotsumoto F et al. Adipose tissue-derived regenerative cells improve implantation of fertilized eggs in thin endometrium. Regen Med 15:1891-1904 (2020). PubMed: 32698666