製品の概要

  • 製品名
    1400W
  • 製品の詳細
    Selective iNOS inhibitor
  • 生理活性の詳細
    Selective iNOS inhibitor, 5000-fold selective over eNOS (Kd values are ≤7 nM, 2 μM and 50 μM at human iNOS, nNOS and eNOS, respectively).
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Hamilton LC & Warner TD Interactions between inducible isoforms of nitric oxide synthase and cyclo-oxygenase in vivo: investigations using the selective inhibitors, 1400W and celecoxib. Br J Pharmacol 125:335-40 (1998). Read more (PubMed: 9786506) »
  • Garvey EP  et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 272:4959-63 (1997). Read more (PubMed: 9030556) »
  • Thomsen LL  et al. Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res 57:3300-4 (1997). Read more (PubMed: 9242464) »

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