Anti-14-3-3 sigma 抗体 (ab94490)

製品の概要

• 製品名
  Anti-14-3-3 sigma antibody
  14-3-3 sigma 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to 14-3-3 sigma
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse, Rat, Sheep, Cow, Pig
• 免疫原

  Synthetic peptide conjugated to KLH derived from within residues 150 to the C-terminus of Human 14-3-3 sigma.

  Immunogen の所有権に関して

• ポジティブ･コントロール
  • This antibody gave a positive signal in Human skin tissue lysate.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファー
  Preservative: 0.02% Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.4
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Neuroscience
  • Neurology process
  • Neural Signal Transduction

  • Signal Transduction
  • Adapters
  • Cytoplasmic

  • Neuroscience
  • Cell Type Marker
  • Neuron marker
  • Synapse marker

  • Stem Cells
  • Signaling Pathways
  • Wnt
  • 14-3-3

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能
  Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
  p53-regulated inhibitor of G2/M progression.
• 組織特異性
  Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
• 配列類似性
  Belongs to the 14-3-3 family.
• 翻訳後修飾
  Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.
• 細胞内局在
  Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway.

• Target information above from: UniProt accession P31947 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 528453 Cow
  • Entrez Gene: 2810 Human
  • Entrez Gene: 55948 Mouse
  • Entrez Gene: 733625 Pig
  • Entrez Gene: 313017 Rat
  • Entrez Gene: 443032 Sheep
  • Omim: 601290 Human
  • SwissProt: Q0VC36 Cow

  • SwissProt: P31947 Human
  • SwissProt: O70456 Mouse
  • SwissProt: O77642 Sheep
  • Unigene: 523718 Human
  • Unigene: 44482 Mouse

  see all
• 別名
  • 14 3 3 protein sigma antibody
  • 14-3-3 protein sigma antibody
  • 1433S_HUMAN antibody

  • Epithelial cell marker protein 1 antibody
  • Er antibody
  • HME 1 antibody
  • HME1 antibody
  • MGC143283 antibody
  • Mkrn3 antibody
  • Mme1 antibody
  • OTTHUMP00000004242 antibody
  • RP23 137L22.11 antibody
  • SFN antibody
  • SFN protein antibody
  • Stratifin antibody
  • YWHAS antibody

  see all

プロトコール

• Western blot protocols