Anti-14-3-3 eta + gamma + zeta 抗体 (ab14124)

製品の概要

  • 製品名
    Anti-14-3-3 eta + gamma + zeta antibody
  • 製品の詳細
    Rabbit polyclonal to 14-3-3 eta + gamma + zeta
  • 特異性
    Recognizes zeta, gamma and eta isoforms at 27kDa in various mammalian systems.
  • アプリケーション
    適用あり: ELISA, WBmore details
    適用なし: IP
  • 種交差性
    交差種: Cow
    交差が予測される動物種: a wide range of other species
  • 免疫原

    Synthetic peptide:

    KMKGDYYRYLAE

    , corresponding to amino acids 124-135 of 14-3-3 eta + gamma + zeta.

  • ポジティブ・コントロール
    • Bovine brain cytosol.
  • 特記事項


    14-3-3 proteins are 30kD polypeptides with nine closely related members in mammals. They are also found in plants and fungi. 14-3-3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins which bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14-3-3 and target proteins are strongly influenced by the phosphorylation state of 14-3-3 and the target protein. 14-3-3 proteins form homo- and hetero-dimeric cup-like structures that bind to discrete phosphoserine-containing motifs. In some instances, 14-3-3 proteins appear to export their binding partners from the nucleus to the cytoplasm in a phosphorylation and Crm1-dependent manner. At least seven isoforms of 14-3-3 have been identified with the zeta isoform being the most broadly expressed in animals.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C. Avoid freeze / thaw cycle.
  • バッファー
    Preservative: None
    Constituents: Whole Serum
  • 精製度
    Whole antiserum
  • 一次抗体 備考
    14-3-3 proteins are 30kD polypeptides with nine closely related members in mammals. They are also found in plants and fungi. 14-3-3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins which bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14-3-3 and target proteins are strongly influenced by the phosphorylation state of 14-3-3 and the target protein. 14-3-3 proteins form homo- and hetero-dimeric cup-like structures that bind to discrete phosphoserine-containing motifs. In some instances, 14-3-3 proteins appear to export their binding partners from the nucleus to the cytoplasm in a phosphorylation and Crm1-dependent manner. At least seven isoforms of 14-3-3 have been identified with the zeta isoform being the most broadly expressed in animals.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab14124 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent dilution.
WB 1/10000. Predicted molecular weight: 27 kDa.
  • 追加情報
    Is unsuitable for IP.
  • ターゲット情報

    • 細胞内局在
      Cytoplasmic
    • 別名
      • 14 3 3 eta antibody
      • 14 3 3 gamma antibody
      • 14 3 3 protein eta antibody
      • 14 3 3 protein gamma antibody
      • 14 3 3 protein zeta antibody
      • 14 3 3 protein zeta/delta antibody
      • 14 3 3 protein/cytosolic phospholipase A2 antibody
      • 14 3 3 zeta antibody
      • KCIP 1 antibody
      • KCIP1 antibody
      • MGC111427 antibody
      • MGC126532 antibody
      • MGC138156 antibody
      • Phospholipase A2 antibody
      • Protein AS 1 antibody
      • Protein AS1 antibody
      • Protein kinase C inhibitor protein 1 antibody
      • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein eta polypeptide antibody
      • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein gamma polypeptide antibody
      • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein zeta polypeptide antibody
      • YWHA 1 antibody
      • YWHA1 antibody
      • YWHAG antibody
      • Ywhah antibody
      • YWHAZ antibody
      see all

    プロトコール

    参考文献

    ab14124 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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