製品の概要

  • 製品名(+)-MK 801 maleate (Dizocilpine)
  • 製品の詳細
    Non-competitive NMDA antagonist
  • 別名
    • Dizocilpine
  • 生理活性の詳細Potent, selective non-competitive NMDA receptor antagonist. Open channel blocker of the NMDA receptor operated ion channel.

    Also available in simple stock solutions (ab144485) - add 1 ml of water to get an exact, ready-to-use concentration.
  • 精製度> 99%

製品の特性

    (+)-MK 801 maleate (Dizocilpine) 画像

    • CDPPB does not influence spontaneous locomotor activity but attenuates MK-801-induced hyperlocomotion. Animals were injected (s.c./i.p.) with PBS/Vehicle (0/0), 0.2 mg/kg MK-801/Vehicle (0.2/0), 0.2 mg/kg MK-801/3 mg/kg CDPPB (0.2/3) or 0.2 mg/kg MK-801/10 mg/kg CDPPB (0.2/10) 20 minutes before being placed in the activity chamber. Activity was recorded for 30 minutes. Data are expressed as mean ± SEM of distance traveled (n=6-7). **p<0.01 vs. 0.2 mg/kg MK-801/Vehicle group (One-way ANOVA, Bonferroni’s posttest).

    (+)-MK 801 maleate (Dizocilpine) (ab120027) 使用論文

    This product has been referenced in:
    • Hatfield RH  et al. The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischaemia model. Eur J Pharmacol 216:1-7 (1992). Read more (PubMed: 1526248) »
    • Woodruff GN  et al. The interaction between MK-801 and receptors for N-methyl-D-aspartate: functional consequences. Neuropharmacology 26:903-9 (1987). Read more (PubMed: 2821432) »
    • Wong EH  et al. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A 83:7104-8 (1986). Read more (PubMed: 3529096) »

    See all 26 Publications for this product

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    Please contact our Australian distributor for the price;

    Sapphire Bioscience Pty Ltd
    126 Cope Street
    Waterloo - NSW
    2017
    Australia

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"