製品の概要

  • 製品名(-)-Deguelin
  • 製品の詳細
    Akt inhibitor. Anticancer agent.
  • 別名
    • (-)-cis-Deguelin
  • 生理活性の詳細Akt inhibitor. Anticancer agent. Inhibits cell growth (IC50 = 43.2 nM) in vitro. Anticancer and antiangiogenic activities in vivo.
  • 精製度> 98%

製品の特性

  • 体系名(7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
  • 分子量394.42
  • 構造式Chemical Structure
  • 分子式C23H22O6
  • CAS 番号522-17-8
  • 保存方法Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in DMSO to 50 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記COc1cc2c(OC[C@H]3Oc4c(ccc5OC(C)(C)C=Cc45)C(=O)[C@@H]23)cc1OC
  • 由来

    Synthetic

  • 研究分野

    (-)-Deguelin (ab120941) 使用論文

    This product has been referenced in:
    • Kang HW  et al. Deguelin, an Akt inhibitor, down-regulates NF-?B signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice. Dig Dis Sci 57:2873-82 (2012). Read more (PubMed: 22623043) »
    • Oh SH  et al. Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha. Int J Cancer 122:5-14 (2008). Read more (PubMed: 17764071) »
    • Murillo G  et al. Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. Eur J Cancer 38:2446-54 (2002). Read more (PubMed: 12460790) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"