製品の概要

  • 製品名
    (-)-Cytisine
  • 製品の詳細
    Potent, selective nAChR agonist
  • 生理活性の詳細
    Potent, selective agonist at neuronal nicotinic receptors. Acts as a partial agonist at β2-containing nicotinic receptors. (Ki values are 2 (α4β2), 5890 (α7), 480 (α3β4), 329 (α6/α4β4) and 492 nM (α1β1γδ)).
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Rollema H  et al. Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. Br J Pharmacol 160:334-45 (2010). Read more (PubMed: 20331614) »
  • LeSage MG  et al. Effects of the nicotinic receptor partial agonists varenicline and cytisine on the discriminative stimulus effects of nicotine in rats. Pharmacol Biochem Behav 91:461-7 (2009). Read more (PubMed: 18817808) »
  • Papke RL & Heinemann SF Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit. Mol Pharmacol 45:142-9 (1994). Read more (PubMed: 8302273) »

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